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Dapsone antibacterial agent, which is active concerning Mycobacterium leprae and tuberculosis. It has bacteriostatic action similar to antagonists of p-aminobenzoic acid.

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Dapsone antibacterial agent, which is active concerning Mycobacterium leprae and tuberculosis. It has bacteriostatic action similar to antagonists of p-aminobenzoic acid.



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Dapsone 10 mg tablet and oral contraceptives for 1 year. The Bactrim order for uti primary end point was occurrence of clinical pregnancy, defined as clinically recognized pregnancy for the first trimester and a live birth by the third day of gestation. secondary end point was a cumulative incidence of clinical pregnancy and a rate for all clinical pregnancies, defined as pregnancy the first occurrence of a clinically recognized pregnancy for the first trimester or live birth by the third day of gestation during the initial period of observation. For these analysis, an independent pregnancy was cost of the drug dapsone defined as the first occurrence of conception before study end. Pregnancy outcomes are reported in Table 1 Table 1. Primary analysis of Pregnancy Rates in the Women Who Received Hormonal Contraceptive Methods during 1 Year: Time from Hormonal Contraceptive To Date of Study Contraception No. Rate Adjusted Rate* No. Rate Adjusted Rate* All pregnancies (n) 14,095 965 3,961 0.78 1.00 20,061 1,094 3,984 0.85 1.09 18,000 1,085 5,006 0.87 2.13 Contraceptive use before study contraception time: 14,088 2,664 5,087 0.89 1.19 9,067 1,096 3,984 0.94 1.18 8,000 1,100 4,738 0.93 Number of first conceptions: 14,082 478 2,908 0.90 1.23 9,065 890 6,004 0.96 1.25 7,800 790 4,038 0.98 1.29 Number of spontaneous abortions: 14,086 676 2,927 0.99 1.36 8,007 885 4,005 1.54 8,000 1,056 4,700 0.97 1.36 Number of clinical pregnancies: 14,111 793 2,982 1.04 1.41 7,818 975 4,738 1.05 1.46 6,800 930 381 0.95 0.90 Number of births: 14,091 593 3,919 1.03 1.54 7,819 1,030 4,007 1.06 1.67 6,800 1,075 4,100 0.99 1.34 Number of spontaneous abortions: 14,100 731 3,969 0.98 1.43 8,005 1,051 4,003 1.05 1.61 7,800 1,070 4,087 0.94 1.33 Number of clinical pregnancy: 14,109 603 3,917 1.02 1.39 7,795 935 4,018 1.03 1.51 7,800 1,071 4,075 0.98 1.36 Live birth by the end of study period: 14,114 763 3,936 1.01 1.52 8,008 938 4,007 1.03 1.61 7,800 1,050 4,062 0.96 1.27 *Adjusted relative risk indicates a statistically significant difference between the groups when relative risk is calculated without the adjustment for potential confounders. Figure 1. View largeDownload slide Relative pregnancy rates on hormonal contraception (pill, shot and ring) over 1 year. *This graphic shows adjusted rates (adjusted by the rate for all spontaneous abortions over pregnancy study period) the period. All values are numbers (percentages) unless stated otherwise. Discussion The purpose of this study was to evaluate the effects of contraceptive pill on the prevalence of abnormal pregnancy rates. These data confirm previous reports of contraceptive-preventive benefits when combined with other strategies to limit the size of future unintended pregnancies The results indicate that use of hormonal contraception is associated with significant reductions in the rate of abnormal pregnancy rates. Specifically, women on hormonal contraception have a much lower incidence of abnormal pregnancy rates than women who did not use contraceptives. The rate of non-pregnancy was significantly lower among women who used contraception, particularly when compared with those who did not use contraceptive methods until the end of observation period (see Box 1). Using hormonal contraception before conception may increase the risk of spontaneous abortion. Women who were using oral contraceptives during the 1st half of study tended to have higher rates of spontaneous abortions than women who were using contraceptives, but there no significant differences between these cohorts in the rate of clinical pregnancy. Box 1. Contraceptive use before study, clinical pregnancy rate.

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